Van een recente literatuurstudie:
Citaat:
Animal and human studies evaluating phytoestrogen effects on the adult hypothalamic–pituitary–gonadal (HPG) axis following adult exposures have been fairly consistent and reveal the potential for suppression. Multiple studies have documented the estrogenic activity of phytoestrogens in ovariectomized rodents [54,235,239] and, in humans, it is generally accepted that consumption of isoflavones-rich soy foods suppresses circulating estrogen and progesterone levels and can attenuate the preovulatory surge of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) [298,179,65]. Notably, however, a handful of studies have found no impact of isoflavones on female hormone levels at all. One of the most recent of these followed 34 women consuming 100 mg of isoflavones per day for a year and found no changes in luteal phase levels of estradiol, estrone, progesterone, SHBG, FSH or LH at months 1, 3, 6 or 12 [162]. Another also failed to find altered circulating gonadal hormone levels in 14 women given soy cookies containing 52 mg of isoflavones or isoflavone-free cookies for 5 days. Interestingly, at least one study found suppressed luteal estradiol levels following increased soy intake, but only in women of Asian descent [298], indicating ethnicity could be an underappreciated factor when considering the potential human health effects of soy isoflavones. With such small samples sizes in all of these studies, however, they may have been too underpowered to detect effects. A 2009 meta-analysis concluded that, in pre-menopausal women, isoflavone intake increases cycle length and suppresses LH and FSH levels [104]. This conclusion is consistent with the clinical case report from SUNY Downstate Medical Center [38] and indicates that use of soy foods should be approached with caution in women attempting to become pregnant or experiencing menstrual cycle irregularities.
Note: Gemiddelde inname (ook met vegetariërs meegenomen) in Nederland van isoflavones is ongeveer 3mg/dag. In deze studies gaat het om 50 - 100 mg/dag. Wanneer je dus een iets hogere inname hebt door het drinken van sojaproducten of het consumeren ervan heeft dat dus tot zover bewezen geen effect. Zeker aangezien er geen eenduidige resultaten worden geboekt wat dus wijst op een variabele. Maar inderdaad, alles met mate.