Maris schreef:Snappen jullie waarom er voor paarden alleen pergolide is in nederland ? Ik lees op engelse sites over bromocriptine, cyproheptadine etc.
edit, ha al gevonden :
The first drug tried in horses with PPID was bromocriptine. Like pergolide, bromocriptine mimics theinhibitory effects of dopamine on the pituitary. It worked, but the problem was it had to be given subcutaneouslyseveral times a day. Oral absorption wasn't reliable.
The drug Cyproheptadine was used at one time to treat horses with PPID. Cyproheptadine blocks serotonin, a brain chemical that stimulates POMC production. Cyproheptadine often works well for a while, then loses its effectiveness. This probably occurs because more dopamine producing neurons continue to be lost and the suppressing effect of blocking serotonin can't compensate for this after a while. The standard dose is 0.25 mg/kg of bodyweight once daily. There is no known documentation of higher doses and/or increased frequency of administering this drug.
Die meds die je noemt zijn in Nederland ook en werden ook gebruikt, met name bromocriptine. Er is vast wel een reden waarom men daar weer vanaf gestapt is.. nu is pergolide (prascend) de drug of choice.
Daarnaast is Trilostane in opkomst na wat recente onderzoeken voor o.a. hoebevangenheid