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**Geplaatst door de TopicStarter** : 17-05-11 19:28

ca/scid

Geplaatst door de TopicStarter : 17-05-11 19:28

Hoi allemaal,

Ik kom elke keer ca/scid tegen bij arabieren maar kan nergens de betekenis ervan vinden,
kan iemand mij dit uitleggen?

Alvast bedankt!

**Geplaatst**: 17-05-11 20:59

Geplaatst: 17-05-11 20:59

Severe Combined Immunodeficiency (SCID). Recessive disorder, fatal when homozygous, carriers (heterozygotes) show no signs. Similar to the "bubble boy" condition in humans, an affected foal is born with no immune system, and thus generally dies of an opportunistic infection, usually before the age of five months. There is a DNA test that can detect healthy horses who are carriers of the gene causing SCID, thus testing and careful, planned matings can now eliminate the possibility of an affected foal ever being born.[45]

Cerebellar abiotrophy (CA or CCA). Recessive disorder, homozygous horses are affected, carriers show no signs. An affected foal is usually born without clinical signs, but at some point, usually after six weeks of age, develops severe incoordination, a head tremor, wide-legged stance and other symptoms related to the death of the purkinje cells in the cerebellum. Such foals are frequently diagnosed only after they have crashed into a fence or fallen over backwards, and often are misdiagnosed as a head injury caused by an accident. Severity varies, with some foals having fast onset of severe coordination problems, others showing milder signs. Mildly affected horses can live a full lifespan, but most are euthanized before adulthood because they are so accident-prone as to be dangerous. As of 2008, there is a genetic test that uses DNA markers associated with CA to detect both carriers and affected animals.[49] Clinical signs are distinguishable from other neurological conditions, and a diagnosis of CA can be verified by examining the brain after euthanasia.[50]

**Geplaatst door de TopicStarter** : 17-05-11 21:33

Geplaatst door de TopicStarter : 17-05-11 21:33

Dankjewel