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Citaat:Prostaglandins in eyelash growth serums and glaucoma medications can cause orbital fat loss, leading to sunken or hollow eyes, a condition called prostaglandin-associated periorbitopathy (PAP). This fat loss results from the shrinking of fat cells in the orbit, causing a recessed eye appearance. While the side effect is usually reversible upon discontinuing the medication, treatment for severe cases may involve fillers or fat grafting, according to the Dove Medical Press.
What is PAP?
PAP describes the cosmetic and clinical changes in the periorbital area that occur with the use of topical prostaglandin analogs, including eyelash growth serums and some glaucoma treatments.
How it happens:
Prostaglandins affect the metabolism of fat cells around the eye.
They cause individual fat cells (adipocytes) to shrink and atrophy, rather than die, leading to overall fat loss in the orbital region.
Common Symptoms:
Hollow or sunken eyes
Deepening of the upper eyelid sulcus: (the crease above the eye)
Flattening of lower eyelid bags
Upper eyelid ptosis: (drooping eyelid)
Mild enophthalmos: (the eye appears more sunken)
Periorbital hyperpigmentation: (darker skin around the eyes)
Reversibility and Treatment:
Discontinuation:
Stopping the use of prostaglandin analogs can lead to some reversal of the condition.
Conservative Management:
For mild changes, no specific treatment may be needed.
Fillers:
In more moderate cases of fat loss, hyaluronic acid fillers can be used to restore volume, according to Dove Medical Press.
Fat Grafting:
Severe cases involving significant fat loss and tissue fibrosis may require autologous fat grafting to restore volume and improve tissue quality.