Double-blinded, Placebo Controlled Study
During the Summer and Fall of 2005 , two highly respected veterinary dermatologists at the University of Florida College of Veterinary Medicine, Gainesville, Drs. Rosanna Marsella and Lisa Akucewich, conducted a double blind investigational study to determine the clinical efficacy and tolerability of topical MedEquine® for the treatment of bacterial skin infections in horses.
In this prospective, double blinded, placebo controlled clinical trial MedEquine® gel significantly decreased the severity of clinical lesions in horses diagnosed with bacterial skin infections after a 4-week treatment. Twenty horses were enrolled in the trial. At the beginning and at the end of the trial (days 0 and 28), horses were evaluated clinically and cytologically for the presence of infection. Owners scored pruritus on a weekly basis. On days 0 and 28 the investigator assigned a clinical score that was the sum of scores assigned to different body regions.
On day 28 a significant decrease of investigator clinical and owners' pruritus scores was observed in the MedEquine® group while the vehicle group did not show any significant change. At the end of the trial, none of the horses in the MedEquine® group required additional therapy while 4/10 horses in the vehicle group required systemic therapy to resolve the infection. MedEquine® gel was well tolerated in all cases. It is concluded that MedEquine® is an effective and safe therapy for the topical management of bacterial skin infections in horses.
Fig. Investigator's clinical scores on days 0 and 28.
N.B. - the lesions of the MedEquine® treated animals progressively improved while the skin lesions of the Vehicle/Placebo treated animals continued to worsen.
Fig. Owner's pruritus scores were assigned on a weekly basis during the trial.
N.B. - the pruritis ( itchiness ) of the MedEquine® treated animals progressively improved while the pruritis of the Vehicle/Placebo treated animals remained the same.
Extracted from
University of Florida's Gainesville Study
bron: www.MedEquine.com