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Fatal Genetic Quarter Horse Disease Identified
by: Kimberly S. Herbert schreef:

An inherited disorder called glycogen branching enzyme
deficiency (GBED) in American Quarter Horses and
related breeds that appears to be the cause for many
unexplained stillbirths and deaths of young foals was
identified by the University of Minnesota's Stephanie
Valberg, DVM, PhD, Department of Clinical and
Population Sciences, and Jim Mickelson, PhD, associate
professor veterinary pathobiology, both in the College
of Veterinary Medicine. The disease was found to be an
autosomal recessive trait, meaning each normal parent
carries one allele that is defective and passes that
"mutant" along to the foal, which ends up with a pair
of defective alleles and expression of the disease.

Citaat:

Consequently, GBE deficiency may be a common cause of neonatal mortality in Quarter Horses that is obscured by the variety of clinical signs that resemble other equine neonatal diseases.

Citaat:

Glycogen Branching Enzyme Deficiency in Foals
by Robert N. Oglesby DVM
Introduction
Glycogen is the chemical name for the complex sugar that our cells make from simple sugar to store for future use. As the glycogen is formed, the glucose strands are branched. As the glycogen is utilized, these branches are broken off as a first step to making energy. Without the branches, only the ends of the long chain can be used and utilization is greatly slowed down.
Dr. Stephanie Valberg and a group of researchers at the University of Minnesota recently found a fatal genetic condition in a small group of related Quarter Horse foals. The condition resulted in abnormal unbranched glycogen. This genetic disease has been reported in humans and cats but not in horses before. Early analysis suggests this is an autosomal recessive disease, which means that for disease to occur the foal must have two copies of this gene on his chromosomes, one obtained from the mare and one from the stallion. However, some siblings and parents that presumably have just one gene and no obvious clinical signs, show some abnormal laboratory values.

The so far identified affected foals have at least 2,600 half-siblings. Consequently, GBE deficiency may be a common cause of neonatal mortality in Quarter Horses that is obscured by the variety of clinical signs that resemble other equine neonatal diseases. This article discusses the clinical and laboratory signs associated with this disease.

Sugarmiss schreef:

Lag het maar zo simpel. Ik denk niet dat men openlijk gaat verkondigen dat zijn hengst (of merrie) een erfelijke ziekte heeft, voorop gesteld dat men het zelf al weet..

piggeljay schreef:

als fokker en handelsstal ben ik van mening dat elke hengst voor hij gaat dekken getest moet worden op erflijke ziektes als je als fokker weet dat er in jou bloedlijnen erflijke ziektes voor komen. bij mijn painthengsten heb ik deze test ook laten doen.