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De acute giftigheid voor zoogdieren, zoals de kat of de mens, valt mee. Pyrethrum wordt in het lichaam snel afgebroken. De dodelijke dosis voor de mens ligt in de buurt van de 100 gram. Pyrethrum kan wel allergische reacties, zoals huiduitslag, veroorzaken bij gevoelige mensen.

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Bovendien is door Rambo gegarandeerd dat de stof tot 25 WASSINGEN blijft zitten op de deken.

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Pyrethroid-based fly sprays
Pyrethroid insecticides are used during the warm seasons on many horses.
They are the most frequently-used insecticides world-wide and are generally considered safe by the EPA.
The labels on the insecticides suggest spraying the horse every few days, or even just once a week.
However the sprays generally are effective for a few minutes, sometimes as much as thirty minutes, so the owners spray their horses repeatedly, or saturate the skin in hopes that the flies will stay away.
The effect is the dose to the horse is significantly higher than the manufacturer has the product labeled for, and the human dose is probably much higher than planned due to the handling of the horse.
Many equine barns have overhead spray systems that put out doses of the spray every few hours or more often.
This spray goes onto the horse, into the water or feed bucket and onto the hay as well as into the respiratory system of the horse.
Horses also reach around and bite at their sides when flies land on them, increasing oral exposure.
The latest insecticide being sold to the horse owner is a super-concentrated pyrethroid to apply in a similar fashion to the dog tick product, Front LineTM.
Owners believe it is the same product due to the marketing the company does.
Some companies are selling their product as all-natural, when in fact, whether naturally derived or synthesized the pyrethrin compound is the same.
Clients believe the companies when they are told the product is all natural, therefore safe.
One study found pyrethroid residues as well as many other herbicide and pesticide residues in animal feed, adding to load already in the body (26).
Overall horses are exposed to high levels of insecticides, both through oral, respiratory and topical routes.
These sprays may be relatively safe at low concentrations, however, no one has studied the effects of the high doses on the animals and people in the barns.
Clients who have converted to non-toxic repellants report that their health is better, and that they have fewer allergies and headaches.
Pyrethroid-based fly sprays (and flea sprays) can depress thyroid function (27, 28, 29) and the thyroid can play a role in insulin resistance as discussed above.
Pyrethroids also have estrogenic activity as do many insecticides, but no progesterone activity in most studies (30, 31). Though it is less relevant to insulin resistance, pyrethroids also affect antibody production and macrophage function (32, 33).
Due to the high concentrations of pyrethrins in many horses’ environments and their ability to disrupt the hormonal system, it would be advisable to reduce the exposure as much as possible.